GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs11190604 | 1 | rs12358187 | chr10:102284449 | SEC31B | chr10:102246403-102289636:- | -0.3 | -11.07 | 4.88E-27 | Palmitoleic acid (16:1n-7) plasma levels |
| BRCA | cis | rs56322409 | 1 | rs12359272 | chr10:97365163 | ENTPD1 | chr10:97471536-97637022:+ | 0.15 | 4.91 | 1.03E-6 | Blood metabolite levels |
| BRCA | cis | rs7927771 | 1 | rs12361031 | chr11:47783076 | MADD | chr11:47290927-47351582:+ | 0.15 | 4.51 | 7.28E-6 | Subjective well-being |
| BRCA | cis | rs7927771 | 1 | rs12361031 | chr11:47783076 | MYBPC3 | chr11:47352958-47374253:- | -0.14 | -4.29 | 1.98E-5 | Subjective well-being |
| BRCA | cis | rs7927771 | 1 | rs12363232 | chr11:47623890 | MADD | chr11:47290927-47351582:+ | 0.13 | 4.04 | 5.75E-5 | Subjective well-being |
| BRCA | cis | rs7927771 | 1 | rs12363232 | chr11:47623890 | MYBPC3 | chr11:47352958-47374253:- | -0.15 | -4.39 | 1.22E-5 | Subjective well-being |
| BRCA | cis | rs948562 | 1 | rs12365551 | chr11:58358368 | CNTF | chr11:58390146-58393203:+ | 0.17 | 3.63 | 0.000291 | Lymphoma |
| BRCA | cis | rs12579753 | 1 | rs12366580 | chr12:82222784 | PPFIA2 | chr12:81652880-82153109:- | 0.14 | 3.51 | 0.000467 | Resting heart rate |
| BRCA | cis | rs7953704 | 1 | rs12366611 | chr12:122607487 | LRRC43 | chr12:122652266-122688017:+ | -0.17 | -4.87 | 1.31E-6 | Urate levels |
| BRCA | cis | rs12579753 | 1 | rs12367791 | chr12:82237278 | PPFIA2 | chr12:81652880-82153109:- | 0.13 | 3.39 | 0.000724 | Resting heart rate |
| BRCA | cis | rs755109 | 1 | rs12377604 | chr9:100697287 | C9orf156 | chr9:100666772-100684852:- | -0.17 | -4.62 | 4.3E-6 | Quantitative traits |
| BRCA | cis | rs1789924 | 1 | rs1238015 | chr4:100281134 | ADH1C | chr4:100257651-100273917:- | -0.21 | -6.72 | 3.03E-11 | Oral cavity and pharyngeal cancer |
| BRCA | cis | rs17401966 | 1 | rs12402052 | chr1:10318652 | PGD | chr1:10459085-10480200:+ | 0.2 | 5.52 | 4.32E-8 | Hepatocellular carcinoma |
| BRCA | cis | rs2275426 | 1 | rs12405451 | chr1:46384326 | CCDC163P | chr1:45960581-45965646:- | -0.4 | -11.82 | 2.23E-30 | Body mass index |
| BRCA | cis | rs2275426 | 1 | rs12405451 | chr1:46384326 | CCDC17 | chr1:46085717-46089729:- | 0.11 | 3.38 | 0.000753 | Body mass index |